BEGIN:VCALENDAR
VERSION:2.0
PRODID:Linklings LLC
BEGIN:VTIMEZONE
TZID:America/New_York
X-LIC-LOCATION:America/New_York
BEGIN:DAYLIGHT
TZOFFSETFROM:-0500
TZOFFSETTO:-0400
TZNAME:EDT
DTSTART:19700308T020000
RRULE:FREQ=YEARLY;BYMONTH=3;BYDAY=2SU
END:DAYLIGHT
BEGIN:STANDARD
TZOFFSETFROM:-0400
TZOFFSETTO:-0500
TZNAME:EST
DTSTART:19701101T020000
RRULE:FREQ=YEARLY;BYMONTH=11;BYDAY=1SU
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20250626T234542Z
LOCATION:B309
DTSTART;TZID=America/New_York:20241118T142100
DTEND;TZID=America/New_York:20241118T142400
UID:submissions.supercomputing.org_SC24_sess753_ws_whpc124@linklings.com
SUMMARY:Event-driven high-performance cloud computing for CRISPR-Cas9 guid
 e RNA design
DESCRIPTION:Divya Joy and Jacob Bradford (Queensland University of Technol
 ogy)\n\nCRISPR-Cas9 has become the gold-standard technology for gene editi
 ng due to its simplicity and low cost. By carefully designing the “guide R
 NA” (gRNA) that directs it to the desired target site, nearly any DNA site
  can be edited. However, selecting good quality gRNA is a complex task and
  can only be achieved with high-performance computers, which are valuable 
 resources that not all are equipped with. Here, we describe our use of eve
 nt-driven cloud computing technologies made available by Amazon Web Servic
 es to overcome challenges faced by traditional standalone software for des
 igning gRNA. Using a cloud-native software template, any researcher can de
 ploy our software, named Crackling-Cloud, to their own cloud environment. 
 This enables them to bring the software to their data, rather than sending
  their data to the software. Crackling-Cloud is available for free on GitH
 ub under the terms of the BSD 3-clause licence: https://github.com/bmds-la
 b/Crackling-AWS\n\nTag: Broader Engagement, HPC in Society, Inclusivity\n\
 nRegistration Category: Workshop Reg Pass\n\nSession Chairs: Elsa J. Gonsi
 orowski (Lawrence Livermore National Laboratory (LLNL)) and Mozhgan Kabiri
  chimeh (NVIDIA Corporation)\n\n
END:VEVENT
END:VCALENDAR